Dietary Supplement Labeling Guide: Chapter III. Net Quantity of Contents

  • What is the net quantity of contents statement for a dietary supplement?

    The net quantity of contents statement for a dietary supplement is the statement that informs consumers of the amount of dietary supplement that is in the container or package.

    21 CFR 101.105(a)

  • Where must I locate the net quantity of contents statement on my label?

    You must locate the net quantity of contents statement on your product label as a distinct item in the bottom 30 percent of the principal display panel, in lines generally parallel with the base of the container. If the principal display panel of your product is 5 square inches or less, the requirement for placement within the bottom 30 percent does not apply when the declaration of net quantity of contents meets the other requirements of 21 CFR 101.

    21 CFR 101.105(f)

  • How must I express the net quantity of contents statement on

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    What You Need to Know

    Many adults and children in the United States take one or more vitamins or other dietary supplements. In addition to vitamins, dietary supplements can contain minerals, herbs or other botanicals, amino acids, enzymes, and many other ingredients. Dietary supplements come in a variety of forms, including tablets, capsules, gummies, and powders, as well as drinks and energy bars. Popular supplements include vitamins D and B12; minerals like calcium and iron; herbs such as echinacea and garlic; and products like glucosamine, probiotics, and fish oils.

    The Dietary Supplement Label

    Products sold as dietary supplements come with a Supplement Facts label that lists the active ingredients, the amount per serving (dose), as well as other ingredients, such as fillers, binders, and flavorings. The manufacturer suggests the serving size, but your healthcare provider might decide a different amount is more appropriate for you.


    Some dietary supplements can help you get adequate amounts

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    Tongkat Ali as a potential herbal supplement for physically active male and female seniors–a pilot study

    Tongkat Ali (Eurycoma longifolia; TA) is known to increase testosterone levels and alleviate aging males’ symptoms. This study aimed at investigating TA as an ergogenic supplement for elderly people. Thirteen physically active male and 12 physically active female seniors (57-72 years) were supplemented with 400-mg TA extract daily for 5 weeks. Standard hematological parameters were taken. In addition, the concentrations of total and free testosterone, dihydroepiandrosterone, cortisol, insulin-like growth factor-1, and sex hormone-binding globulin were analyzed. As additional biochemical parameters, blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage, respectively, as well as the muscle strength by a simple handgrip test were determined. After treatment, hemoglobin, testosterone, and dihydroepiandrosterone concentrations, and the ratio of total testosterone/cortisol and muscle force remained significantly lower in female seniors than in male seniors. Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female

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    Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials


    . 2020 Jul;34(7):1550-1555.

    doi: 10.1002/ptr.6627.

    Epub 2020 Feb 11.


    Item in Clipboard


    Anahita Mansoori et al.

    Phytother Res.

    2020 Jul.

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    24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain


    Collagen hydrolysate is a nutritional supplement that has been shown to exert an anabolic effect on cartilage tissue. Its administration appears beneficial in patients with osteoarthritis.


    To investigate the effect of collagen hydrolysate on activity-related joint pain in athletes who are physically active and have no evidence of joint disease.

    Design and setting:

    A prospective, randomized, placebo-controlled, double-blind study was conducted at Penn State University in University Park, Pennsylvania. Parameters including joint pain, mobility, and inflammation were evaluated with the use of a visual analogue scale during a 24-week study phase.

    Study participants:

    Between September 2005 and June 2006, 147 subjects who competed on a varsity team or a club sport were recruited. Data from 97 of 147 subjects could be statistically evaluated.


    One hundred and forty-seven subjects (72 male, 75 female) were randomly assigned to two groups: a group (n = 73) receiving 25 mL of

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    Force Health Protection Guidance (Supplement 17) Revision 1

    Today, the department released the memo for Force Health Protection Guidance (Supplement 17) Revision 1 – DoD Guidance for the Use of Masks, PPE, and Non-Pharmaceutical Interventions During the COVID-19 Pandemic. 

    This memorandum rescinds Acting Under Secretary of Defense for Personnel and Readiness Memorandum “Force Health Protection Guidance (Supplement 17)- Department of Defense Guidance for the Use of Masks, Personal Protective Equipment, and Non¬Pharmaceutical Interventions During the Coronavirus Disease 2019 Pandemic,” March 17, 2021, and supplements Secretary of Defense Memorandum, “Use of Masks and Other Public Health Measures,” February 4, 2021, and Deputy Secretary of Defense Memorandum, “Updated Mask Guidelines for Vaccinated Persons,” May 13, 2021, with updated guidance on the use of masks in conjunction with other public health measures, including non-pharmaceutical interventions (NPIs), during the coronavirus disease 2019 (COVID-19) pandemic. 

    This memorandum includes updated guidance for fully vaccinated personnel. It maintains guidance on use of personal protective equipment

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    Michigan to restore work-search rule, keep $300 supplement

    LANSING, Mich. (AP) — Michigan will reinstate a requirement that people receiving unemployment benefits show they are actively searching for work, effective May 30, but has no plan to end a $300 weekly federal supplement going to 816,000 jobless residents.

    All seven of the state’s Republican U.S. House members wrote a letter to Democratic Gov. Gretchen Whitmer on Monday urging a halt to the extra payment, which is on top of maximum state benefits of $362 per week.

    “We call on you to end participation in this program to get our state’s economy back on track and ensure our employers have access to the talent they need to return to normal,” they said, citing rising vaccination rates and echoing a call that at least one small business group made last week. They said the benefits are too robust, incentivizing the unemployed to not return to work.

    But Lynda Robinson, spokeswoman

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    Charlotte’s Web Completes Filing of Prospectus Supplement for At-the-Market Equity Program | Cannabis


    ATM program adds optionality to capital liquidity toolbox

    BOULDER, Colo., June 4, 2021 /CNW/ – (TSX: CWEB) (OTCQX: CWBHF) Charlotte’s Web Holdings, Inc. (“Charlotte’s Web” or the “Company”) has filed a prospectus supplement to establish an at-the-market equity program (the “ATM Program”). The Company may distribute up to CAD$60 million of common shares of the Company (the “Offered Shares”) under the ATM Program. Any distributions of the Offered Shares through the ATM Program will be made pursuant to the terms of an equity distribution agreement (the “Distribution Agreement”) with Canaccord Genuity Corp. and BMO Nesbitt Burns Inc. (together, the “Agents”). The Offered Shares may be issued by the Company to the public from time to time, through the Agents, at the Company’s discretion. The Offered Shares sold under the ATM Program, if any, will be sold at the prevailing market price

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    Weight Loss Supplement Market Research Report by

    New York, June 08, 2021 (GLOBE NEWSWIRE) — announces the release of the report “Weight Loss Supplement Market Research Report by Distribution Channel, by Region – Global Forecast to 2026 – Cumulative Impact of COVID-19” –

    The Global Weight Loss Supplement Market size was estimated at USD 81.57 Billion in 2020 and expected to reach USD 87.70 Billion in 2021, at a Compound Annual Growth Rate (CAGR) 7.84% from 2020 to 2026 to reach USD 128.36 Billion by 2026.

    Market Statistics:
    The report provides market sizing and forecast across five major currencies – USD, EUR GBP, JPY, and AUD. It helps organization leaders make better decisions when currency exchange data is readily available. In this report, the years 2018 and 2019 are considered historical years, 2020 as the base year, 2021 as the estimated year, and years from 2022 to 2026 are considered the forecast period.

    Market Segmentation

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    This supplement can reduce methane in cows and make farmers money

    A big chunk comes from the methane cows emit, but a new feed supplement could reduce those emissions by an average of 30%, according to its makers. If all the world’s cows ate the supplement, the reduction in emissions could be equivalent to taking more than 300 million cars off Europe’s roads.

    Developed by Swiss-British startup Mootral, the supplement, based on garlic and citrus extracts, is mixed with regular cattle feed, reducing methane emissions by the equivalent of around one ton of carbon dioxide per cow per year.

    The company is now converting these savings into carbon credits — approved by Verra, a global program for voluntary carbon offsets — that are sold to businesses that want to offset their emissions.

    Proceeds from the sale of the carbon credits go back to the farmers, subsidizing the initial cost of the feed and encouraging them to buy more, Mootral CEO Thomas … Read More

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